Helen Angell-澳门在线赌城娱乐

Helen Angell is a Director in the Oncology, Translational Science team in Cambridge, UK

Helen received her Ph.D. 诺丁汉大学药学院的“肿瘤微环境的免疫调节”, funded by AstraZeneca and EPSRC (Engineering and Physical Sciences Research Council). Upon completing her doctorate, 海伦开始在科德利埃斯研究中心的综合免疫学实验室工作, Paris. A joint MedImmune-funded postdoc, here Helen was involved in the development and implementation of the ‘Immunoscore’. In addition, 海伦对免疫亚群的特征和表型进行了研究, cytokines, chemokines and tumour alteration, associated with colorectal cancer progression, recurrence and metastasis.

In January 2014, Helen joined AstraZeneca’s Oncology Translational Medicine Team. Since then Helen has focussed on development of the leading Immuno-Oncology portfolio, 设计免疫治疗和小分子联合研究的分割策略，以加强临床试验的患者选择, 并领导外部合作，进一步加速这一领域的科学进步. Helen also led the team who developed the Tumor & Immune Cell Atlas (TICA), 生成疾病关联数据以指导临床试验中患者选择的核心倡议.

IMMUNE PROFILING STRATEGY

为临床项目提供免疫专业知识和管理免疫肿瘤学转化科学方面的贡献, e.g. Tagrisso and Iressa

IMMUNO-ONCOLOGY DISEASE POSITIONING FOR NOVEL INDICATIONS

表征免疫表型和基因组畸变在不同的肿瘤适应症作为肿瘤进展的决定因素, with the aim to identify novel biomarkers for better clinical management of cancer, including improved prediction of prognosis, patient stratification and tumour monitoring

PLATFORM DEVELOPMENT FOR MEASUREMENT OF IMMUNE PARAMETERS

Development of novel analytical techniques, including IHC digital image analysis and multiplexing, 为免疫生物标志物的可靠定量，为小分子/免疫肿瘤学项目提供更有力的支持

GROUND-BREAKING PATIENT STRATIFICATION

Design and implementation of the Immunoscore. For the first time, 肿瘤的进展和侵袭在统计学上依赖于宿主免疫反应, where the immune pattern remained the only significant criteria over TNM-classification

ARTICLE PUBLISHED

提高肿瘤免疫细胞密度作为预后因素的重要性，以帮助预测癌症生存和复发风险. Correlating microsatellite instability status with genetic and genomic changes, the TME immune profile and the Immunoscore, in relation to colorectal patient survival

Featured publications

Susan M Domchek, Sophie Postel-Vinay, Seock-Ah Im, Yeon Hee Park, Jean-Pierre Delord, Antoine Italiano, Jerome Alexandre, Benoit You, Sara Bastian, Matthew G Krebs, Ding Wang, Saiama N Waqar, Mark Lanasa, Joon Rhee, Haiyan Gao, Vidalba Rocher-Ros, Emma V Jones, Sakshi Gulati, Anna Coenen-Stass, Iwanka Kozarewa, Zhongwu Lai, Helen K. Angell, Laura Opincar, Pia Herbolsheimer, Bella Kaufman. The Lancet Oncology

Daniela Bruni*, Helen K. Angell*, and Jérôme Galon. Nature Reviews Cancer

肿瘤微环境和免疫评分是扩散到远处转移的关键决定因素. Bernhard Mlecnik, Gabriela Bindea, Amos Kirilovsky, Helen K. Angell, Anna C. Obenauf, Marie Tosolini, Sarah Church, Pauline Maby, Tessa Fredriksen, Stéphanie Mauger, Anne Berger, Michael R. Speicher, FranckPagès, Viia Valge-Archer, Jérôme Galon. Science Translational Medicine, 2016.

结直肠癌的综合分析显示免疫评分比微卫星不稳定性更能预测患者的生存. Bernhard Mlecnik, Gabriela Bindea, Helen K Angell, Pauline Maby, David Tougeron, Lucie Lafontaine, Mihaela Angelova, Tessa Fredriksen, Maristella Sasso, Amélie M. Bilocq, Anna C. Obenauf, Anne Berger, Patrick Bruneval, Florence Le Pessot, Arash Rafii, Michael R. Speicher, Zlatko Trajanoski, Richard Sesboüe, Thierry Frebourg, FranckPagès, Viia Valge-Archer, Jean-Baptiste Latouche, Jérôme Galon. Immunity, 2016.

微卫星不稳定结直肠癌中CD8+ t细胞浸润密度与移码突变的相关性:个体化免疫治疗的基本原理. Pauline Maby, David Tougeron, Bernhard Mlecnik, Mohamad Hamieh, Gabriela Bindea, Helen K Angell, Tessa Fredriksen, Nicolas Elie, Emilie Fauquembergue, Jacques Benichou, Florence Le Pessot, Richard Sesboue, Thierry Frebourg, Jerome Galon, Jean-Baptiste Latouche. Cancer Research, 2015.

结直肠癌抗肿瘤免疫应答需要CXCL13-CXCR5信号传导. Maximilian J. Waldner, Gabriela Bindea, Bernhard Mlecnik, Helen K. Angell, Sebastian Foersch, Uta E. Höpken, Stefan J. Wirtz, Christoph Becker, Markus F. Neurath, Jérôme Galon. Gastroenterology, 2014.

肿瘤内细胞的时空动态揭示了人类癌症的免疫景观. Gabriela Bindea, Bernhard Mlecnik, Marie Tosolini, Amos Kirilovsky, Maximilian Waldner, Anna C. Obenauf, Helen K. Angell, Tessa Fredriksen, Lucie Lafontaine，安妮·伯杰，帕特里克·布鲁瓦尔，沃尔夫·赫尔曼·弗里德曼，克里斯托弗·贝克尔，弗兰克·帕格瑞斯，迈克尔·R. Speicher, Zlatko Trajanoski, Jérôme Galon. Immunity, 2013.

癌症免疫监测的连续性:预后、预测和机制特征. Jérôme Galon, Helen K. Angell, Davide Bedognetti, and Francesco Marincola. Immunity, 2013.

Microenvironnement immunitaire et survie : l’Immunoscore. Jérôme Galon, Gabriela Bindea, Bernhard Mlecnik, Helen Angell, Christine Lagorce, Anne Berger, FranckPagès. Medicine and Science, 2014. Epub 2014 May 5.

功能网络量身定制的管道揭示了与原位淋巴细胞增殖和癌症患者生存相关的肿瘤遗传决定因素. Bernhard Mlecnik, Gabriela Bindea, Helen K. Angell, Maria Stella Sasso, Anna C. Obenauf, Tessa Fredriksen, Lucie Lafontaine, Amelie M. Bilocq, Amos Kirilovsky, Marie Tosolini, Anne Berger, Wolf Herman Fridman, Arash Rafii, Viia Valge-Archer, Franck Pagès, Michael R. Speicher, Jérôme Galon. Science Translational Medicine, 2014.

The immune landscape of human tumors. Gabriela Bindea, Bernhard Mlecnik, Helen K Angell, Jérôme Galon. Oncoimmunology, 2014.

Towards the introduction of the Immunoscore in the classification of malignant tumors. Jérôme Galon, Bernhard Mlecnik, Gabriela Bindea, Helen K Angell, Anne Berger, et al. Journal of Pathology, 2014.

Gabriela Bindea, Bernhard Mlecnik, Marie Tosolini, Amos Kirilovsky, Maximilian Waldner, Anna C. Obenauf, Helen K. Angell, Tessa Fredriksen, Lucie Lafontaine，安妮·伯杰，帕特里克·布鲁瓦尔，沃尔夫·赫尔曼·弗里德曼，克里斯托弗·贝克尔，弗兰克·帕格瑞斯，迈克尔·R. Speicher, Zlatko Trajanoski, Jérôme Galon. Immunity, 2013.

基于数字模式识别的图像分析能够可靠地量化结直肠癌不同组织区域的免疫浸润，并识别潜在的转移表型. H.K. Angell, N. Gray, C. Womack, D.I. Pritchard, R.W. Wilkinson, M. Cumberbatch. British Journal Cancer, 2013.

癌症免疫监测的连续性:预后、预测和机制特征. Jérôme Galon, Helen K. Angell, Davide Bedognetti, and Francesco Marincola. Immunity, 2013.

从免疫环境到免疫评分:癌症预后和预测免疫标志物的作用. Helen Angell and Jérôme Galon. Current Opinion in Immunology, 2013.

Cancer classification using the Immunoscore: A worldwide task force. Jérôme Galon, Franck Pagès, Francesco M Marincola, Helen K Angell, et al. Journal Translational Medicine, 2012.

Survivin定位在耐药细胞凋亡中的潜在作用研究. Angell, H. Bioscience Horizons, 2008.

人晶状体上皮细胞中tgf β亚型依赖的Smad2/3动力学:细胞组学分析. Dawes LJ, Angell H, Sleeman M, Reddan JR, Wormstone IM. Experimental Eye Research, 2007.

国际验证的共识免疫评分结肠癌的分类:预后和准确性的研究. The Lancet, 2018. Franck Pagès, Bernhard Mlecnik, Florence Marliot, Gabriela Bindea, Fang-Shu Ou, Carlo Bifulco, Alessandro Lugli, Inti Zlobec, Tilman T Rau, Martin D Berger, Iris D Nagtegaal, Elisa Vink-Börger, Arndt Hartmann, Carol Geppert, Julie Kolwelter, Susanne Merkel, Robert Grützmann, Marc Van den Eynde, Anne Jouret-Mourin, Alex Kartheuser, Daniel Léonard, Christophe Remue, Julia Y Wang, P Bavi, Michael H A Roehrl, Pamela S Ohashi, Linh T Nguyen, SeongJun Han, Heather L MacGregor, Sara Hafezi-Bakhtiari, Bradly G Wouters, Giuseppe V Masucci, Emilia K Andersson, Eva Zavadova, Michal Vocka, Jan Spacek, Lubos Petruzelka, Bohuslav Konopasek, Pavel Dundr, Helena Skalova, Kristyna Nemejcova, Gerardo Botti, Fabiana Tatangelo, Paolo Delrio, Gennaro Ciliberto, Michele Maio, Luigi Laghi, Fabio Grizzi, Tessa Fredriksen, Bénédicte Buttard, Mihaela Angelova, Angela Vasaturo, Pauline Maby, Sarah E Church, Helen K Angell, Lucie Lafontaine, Daniela Bruni, Carine El Sissy, Nacilla Haicheur, Amos Kirilovsky, Anne Berger, Christine Lagorce, Je rey P Meyers, Christopher Paustian, Zipei Feng, Carmen Ballesteros-Merino, Jeroen Dijkstra, Carlijn van de Water, Shannon van Lent-van Vliet, Nikki Knijn, Ana-Maria Mușină, Dragos-Viorel Scripcariu, Boryana Popivanova, Mingli Xu, Tomonobu Fujita, Shoichi Hazama, Nobuaki Suzuki, Hiroaki Nagano, Kiyotaka Okuno, Toshihiko Torigoe, Noriyuki Sato, Tomohisa Furuhata, Ichiro Takemasa, Kyogo Itoh, Prabhu S Patel, Hemangini H Vora, Birva Shah, Jayendrakumar B Patel, Kruti N Rajvik, Shashank J Pandya, Shilin N Shukla, Yili Wang, Guanjun Zhang, Yutaka Kawakami, Francesco M Marincola, Paolo A Ascierto, Daniel J Sargent*, Bernard A Fox, Jérôme Galon

Award

2013 Young Investigator Award, Society for Immunotherapy of Cancer (SITC)

Award

2011, The Richard Hambro Award, NCRI Cancer conference

Award

2008 Bioscience Horizons Young Scientist Award

AstraZeneca’s progress in the immuno-oncology field fills me with great excitement! 澳门第一赌城在线娱乐的新数据将帮助澳门第一赌城在线娱乐识别和验证患者的生物标志物和潜在的治疗靶点, which may enable better treatment decisions, 同时也为澳门第一赌城在线娱乐先进的DNA损伤反应组合提供了新的机会.

Helen Angell Director, Translational Medicine, Oncology Research & Early Development